What is Taxol?
Taxol was discovered in 1962 as a result of a U.S. National Cancer Institute-funded screening program; Monroe Wall and Mansukh Wani isolated the drug from the bark of the Pacific yew, Taxus brevifolia, and named it "taxol".
Taxol is a mitotic inhibitor drup used in the treatment of cancer. It was discovered at Research Triangle Institute (RTI) in 1967 when Monroe E. Wall and Mansukh C. Wani isolated the compound from the bark of the Pacific yew tree, Taxus brevifolia, and noted its antitumor activity in a broad range of rodent tumors. By 1970, the two scientists had determined the structure of paclitaxel. Paclitaxel has since become an effective tool of doctors who treat patients with lung, ovarian, breast cancer, and advanced forms of Kaposi's sarcoma. It is sold under the tradename Taxol. Together with docetaxel, it forms the drug category of the taxanes.
1. Taxol is a mitotic inhibitor drup used in the treatment of cancer.
2. Isolated the compound from the bark of the Pacific yew tree, Taxus brevifolia, and noted its antitumor activity in a broad range of rodent tumors.
3. Taxol has since become an effective tool of doctors who treat patients with lung, ovarian, breast cancer, and advanced forms of Kaposi's sarcoma.
4. Taxol is also used for the prevention of restenosis (recurrent narrowing) of coronary stents; locally delivered to the wall of the coronary artery, a paclitaxel coating limits the growth of neointima (scar tissue) within stents.
How Taxol works:
Paclitaxel belongs to the group of cancer-fighting medications known as antineoplastics. Paclitaxel works by slowing or stopping the growth of cancer cells in your body. Paclitaxel is used alone or in combination with other cancer medications to treat cancers of the ovary, breast, or lung. It may also be used to treat another form of cancer called Kaposi's sarcoma.
See literature. Premedicate with corticosteroids, diphenhydramine, H2 antagonists. Breast cancer (node-positive): 175mg/m2 IV over 3 hours every 3 weeks for 4 courses administered sequentially to doxorubicin-containing combination chemotherapy. Breast cancer (after failure of initial chemotherapy for metastatic disease or relapse): 175mg/m2 IV over 3 hours every 3 weeks. Hepatic impairment or neutropenia: see literature for dose modifications. Do not treat if neutrophil count <1,500cells/mm3 or platelets <100,000cells/mm3.
Therapy should not be administered to patients with baseline neutrophil counts < 1,500 cells/mmÂ³. Courses of therapy should not be repeated until the neutrophil count is at least 1500 cells/mmÂ³ and platelet count is at least 100,000 cells/mmÂ³. Paclitaxel should be immediately discontinued in patients developing severe reactions including hypotension requiring treatment, dyspnea requiring bronchodilators, angioedema or generalized urticaria. Patients developing severe hypersensitivity reactions should not be rechallanged.
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