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What is Polydatin

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If this is the first time you are reading about polydatin, you might pose and ask what is polydatin? Polydatin is also called piceid. It is a resveratrol glucoside. This implies that it is a resveratrol that is joined to the sugar molecule. In most scientific documents, it is called piceid by most scientists. However, polydatin is the most popular name for it in supplements or in daily life. It has several health benefits which include protecting the liver from tetrachloride-induced injury, preventing cancer and lowering cholesterol. It cleaves off its sugar molecule after entering the bloodstream. This implies that the rate at which the resveratrol glucoside is absorbed is different from that of the standard trans-resveratrol. This increases the potency and half-life of this resveratrol. It is commonly found in grape juices and Picea sitchensis’ bark. It is also isolated from the Japanese knotweed, Polygonum cuspidatum. Nevertheless, there are side effects such as nausea, diarrhea and vomiting that you should be wary of before using it.

Polydatin benefits

Use polydatin to prevent cancer — According to a study that was published by the Journal of Translational Medicine in 2003, polydatin can be used in preventing cancer. The scientific mechanism behind this ability of polydatin is the presence of chrysophanol and emodin which have anti-mutagenic properties. This implies that these substances decrease the rate at which cancer cells mutate. Mutation is usually the beginning of cancer in humans. Therefore, these substances act like cancer preventers.

Use polydatin to lower high cholesterol — Polydatin has been used in Japan and China to lower high cholesterol in human body for many centuries. According to a research by the Department of Pharmacology in the Military University in Shangai, polydatin decreases the total cholesterol level in the serum. The scientific mechanism behind this activity of polydatin is its ability to develop a hepatoprotective and/or hypolipemic agent which lowers cholesterol level in the body. However, the study suggested the need for further research to determine the mechanism of the hypolipemic action.

Take polydatin to protect the liver from tetrachloride-induced injury—Polydatin has the ability to protect and nourish the liver. According to a study that was published by the Public Library of Science, polydatin has anti inflammatory and antioxidant stress effects. It can also act as an effective hepatoprotective agent, which can effectively be used in treating oxidative stress as well as inflammation-related diseases.

Polydatin dosage


  • To lower cholesterol, take up to 100 mg of polydatin per day in two portions orally. 
  • To protect the liver from tetrachloride-induced injury, take between 250 and 500mgs of polydatin per day orally.
  • To prevent cancer, take between 1 and 4 capsules of 500mgs each per day.


Polydatin Side effects

If you have been wondering what is polydatin, now you know. Perhaps, polydatin’s possible effects are now your major concern. The most common side effects of polydatin that you should be wary of before using it as a treatment include nausea, diarrhea and vomiting. These are commonly caused by the use of polydatin in wrong dosage. To avoid these side effects, use polydatin as prescribed by the manufacturer. Also consult your doctor before taking it.

Warnings

Although polydatin is generally safe, pregnant and breastfeeding women should not use it because there is no adequate information regarding its safety on them.

References:

  1. Department of Pharmacology, Second Military University, Shanghai: Polydatin effects from polygonum cuspidatum on the lipid profile of hyperlipidemic rabbits
  2. Public Library of Science: Polydatin protective effects from polygonum cuspidatum against the carbon tetrachloride-induced injury of the liver in mice
  3. Transnational Medicine Journal: Polydatin, the natural resveratrol precursor induces arrest for cell cycle and differentiation of caco-2 cell human colorectal

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