Osthole is derived from the seeds of the Cnidium monnieri plant which is mainly found in China. Also known as She Chuang Zi in China, Osthole features in many Chinese herbal medicines and health supplements. It is cures several ailments ranging from skin problems, lack of libido, osteoporosis, inflammation, tumors and much more. The Osthole benefits includes anti-oxidation, anti-osteoporosis, anti-inflammation and more. However, there are concerns about side effects that come with using this substance especially in high doses. People are therefore advised to seek medical advice before using Osthole .
According to studies undertaken byGannan Medical College in China, Osthole was effective in controlling the inflammation that comes with nitric oxide. The study which was done on mice followed a dose-dependent approach and indicated that the compound suppressed entry of calcium while increasing cGMP. This makes it suitable for people who suffer from chronic ailments that are usually caused by high levels of nitric oxide, and free-radicals, among other harmful compounds .
Osthole differentiates and also stimulates the production of Osteoblasts-like cells in the human body. The induction of hFOB and MG-63 helps in reducing the negative effects that come with osteoporosis. This is according to scientific research done by scientists from the Chia-Nan University, School of Science and Pharmacy. The study further revealed that Osthole shared similarities with 17beta-estradiol and could suppress the loss of bones. This was based on findings done on ovariectomized rats .
Treatment of Liver Cancer
One of the possible key Osthole benefits is the treatment of cancer of the liver. In a study conducted by Nippon Chemiphar Company, Osthole increases the production of essential hormones that are effective against cancerous cells. It also combats free radicals that contribute to aging or high toxicity in the level. This is credited to its unique chemical structure and composition (butenyl group position-8) . According to Xian Medical University research findings, Osthole could help improve the health of lungs especially amongst smokers. Studies done on guinea pigs indicated that Osthole reduced the condensation brought about by lipopolysaccharide and cigarette smoke by combating histamine (His),acetylcholine (ACh), and KCl .
Effective against Hypertension
In reference to research undertaken by The National Taiwan University, Osthole which was already categorized as an anti-platelet agent suppressed tonic and norepinephrine -induced phasic contractions in rats. It also blocked Ca (2+)-channel and increased cGMP levels in the aorta and vascular muscles leading to relaxation . Researchers from University of Soochow,School of Medicine, China tested the compound on lab mice and found that it inhibited the production of fat in the liver of the mice. It was also found to stall the absorption of alcohol into the blood stream. This was attributed to the suppression of production TNF-alpha hormone and also anti-oxidation properties .
Potential Side Effects
Most of the studies focus on Osthole benefits and seem to indicate that it doesn’t have any major side effects. However, people are warned against consuming high doses as this could lead to sleep disturbances, irritability, and also quick heart pulse. Furthermore, some studies such as how it effectively aids in bone loss is still ongoing .
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