The Basic Definition of Celastrol
If you will ask the question "What is Celasteol, and what does it do?", this guide is for you. Celastrol is an active ingredient, a quinone methide triterpene extracted from the roots and leaves of the Chinese medicinal plant known as the "Thunder of God Vine", Tripterygium wilfordii. Celastrol is primarily used to treat RA, or rheumatoid arthritis, multiple sclerosis, heavy menstrual flows, and as a contraceptive for males.
The History and Discovery of Celastrol
The extract that comes from the Thunder God Vine has had a long and illustrious history as a component of Chinese medicine. Incidentally and during the last few decades, worldwide obesity has become such a problem that researchers spend a considerable amount of time and effort to curb it by exploring how leptin works against suppressing appetite and making patients lose body fat and weight. Recent light has focused on Celastrol as a possible supplement for many various ailments and provided a direct answer on how it alleviated resistance to leptin, in a research done on mice. This has led to more research as there are a few more unknown factors and variables to explore.
The Many Benefits of Celastrol
Celastrol has many known benefits listed comprehensively below:
- It was used as a staple Chinese medicine to treat rheumatoid arthritis by providing anti-inflammatory effects, giving relief in those who experience chronic distress by heredity or old age. Patients reported and show improvement in important areas such as inflammation of the joints, less swelling in the joint area, and a significantly reduced joint pain. Celastrol is also found to forestall Alzheimer's disease and shorten asthma attacks, plus it aids in keeping systemic lupus erythematosus at bay.
- Celastrol was also found to have promising anti-cancer properties: in a study, it induced apoptosis and inhibited protosomeal activity in prostrate cancer cells and human breast samples.
- The medicine can help all women relieve some of their most stressful days by ingesting it and having their menstrual periods alleviated.
- Celastrol can also benefit various other diseases and complications such as lupus and multiple sclerosis.
- Celastrol treatment can also lead to a suppression of an over-active immune system.
- As mentioned above, the most promising effect of Celastrol is its effect on obesity and its inherent abilities in leptin suppression. This will be covered in another section.
Take Celestrol for Weight Loss?
In an experiment with Celastrol and lab mice, doctors and researchers have shown promising results in the fight against obesity and its exact cause. Mice that took this medicine limited their food intake up to a maximum of 80%, which had them lose about 45% of their body weight when they started the experiment in only a span of three weeks. How does it do this? Celastrol itself enhances leptin, which is a hormone that suppresses the appetite naturally. Not only that, but it can potentially affect obesity-associated conditions such as a fatty liver, type 2 diabetes, and various heart diseases.
Leptin is often the key research in treating obesity. It signals the brain and tells it to stop mindless eating when the body reaches sufficient fuel and energy levels. A significant lack of leptin hormone in humans and mice will lead to them eating voraciously, becoming more and more obese without any indication given by the body to stop. It is not that simple, as studies also prove that an increase of the leptin hormone in the body does not necessarily mean a repressed appetite. Factors suggest that leptin can be very sensitive or insensitive, and is a different case for each person.
A very dramatic weight loss result is what excites researchers to find out more information about Celastrol. It produces a very quick fat loss effect when compared to bariatric surgery. Add to the fact that Celastrol reduced levels of cholesterol, improved the liver's function and its glucose metabolism- leading to benefits of a lower heart risk, type 2 diabetes, and a fatty liver.
Side Effects of Celastrol
Thunder God Vine's side effects are documented in cases where it was used to treat various ailments. Depending on the overall dosage, Celastrol can have a potentially negative and severe complications. The skinned root and leaves have to be prepared properly, or else it will be highly poisonous.
In the preceding studies and researches shown above, adverse gastrointestinal side effects such as nausea, indigestion and diarrhea was present and experienced by many test subjects. There were also cases of upper respiratory tract infections. It may also possibly cause non-direct and lasting side effects such as migraines, menstrual changes, skin rashes and hair loss.
Celastrol can also be dormant and lay in wait until a longer period has passed, then have a long-term side effect suddenly come up. Women who have participated and those who have habitually taken the herb in a span of 5 years and longer have been examined and shown to have decreased bone strength with lack of bone mineral deposits. High dosages of Celastrol is not recommended as it can severely weaken a person's autoimmune system. People with HIV/AIDS should stay away from consuming this supplement. It may also adversely affect male fertility by changing sperm count and potency.
How Does Celastrol Work?
Celastrol is an agent that has many properties, most notably being antioxidant and anti-inflammatory. It is a HSP90 inhibitor that works as an anti-cancer component, and it works against weight loss by interacting directly with leptid, hormones that are responsible for suppressing hunger pangs.
Now that we have answered the question of What is Celastrol, the last part would be the correct dosage of this wonder supplement. A weight loss supplement can include Celastrol as a main ingredient. It should be duly noted, however that this ingredient has a low index in therapeutic rankings, that it would be best to consult a doctor or a physician first to get professional advice before taking Celastrol for its benefits. Expect a rapid development of this up-and-coming popular ingredient being introduced to the market much sooner than you would think.