Naringin is a natural bioflavonoid compound contained in the inner peel and pulp of grapefruit and other citrus fruits and is responsible for their typical bitter flavor. Essentially, it is classified as a water soluble phytochemical flavonoid that contributes to potential nutritional and health benefits of the grapefruits. Numerous studies have revealed its potential antioxidant, anti-carcinogenic, anti-inflammatory and other pharmacological properties. Its antioxidants property helps to prevent cancer, inhibits hardening of the arteries by high cholesterol levels and regulates blood sugar levels.
Naringin contains potent anti-cancer benefits; a rat based publication in the Anticancer Research showed that Naringin enhanced a therapeutic treatment of rats infected with walker 256, a tumor disease that causes cachexia; cachexia is a cancerous syndrome that contributes to 80% of the malignant related diseases in humans. Naringin inhibits tumor growth and enhances the reduction of proinflammatory cytokines which causes tumor immunosuppression and tumor cell proliferation.
Naringin contains anti-diabetic properties; a study published in the Journal of Nutrition showed that Naringin increases liver efficiency, which enhances the regulation and uptake of glucose among cells. Besides, it ensures increased levels of glycogen in the blood, thus reduce the blood sugar levels in patients diagnosed with diabetes type 2 and poor glucose control or heightened glucose tolerance. Another research has shown that Naringin prevents cataracts eye damage in patients with diabetes, a condition that occurs as a result of the breakdown and accumulation of sugar products in the lens of the eye.
Naringin promotes cardiovascular health. A Phytotherapy Research showed that the antioxidant property of Naringin prevents oxidation of low density lipoprotein (LDL), regarded as bad cholesterol which lower triglycerides and LDL cholesterol levels in the blood, thus preventing the risk of atherosclerosis, a condition associated with hardening of arteries leading to hypertension and heart attack. Besides, it promotes high-density lipoprotein (HDL) cholesterol, also regarded as good cholesterol, which helps to remove the excess cholesterols deposits thus improving the arterial function and cardiovascular health.
Naringin supports memory and cognitive function. A research published in the Journal of Agriculture and Food Chemistry showed that Naringin acts as potent antioxidant and an efficient modulator of neurotransmitter, which prevent the oxidative damage of free radicals and the inflammation of brain tissues; this lowers cellular deterioration of brain tissues, promotes healthy brain tissues, and enhanced cognitive function. Besides, the antioxidant property plays a crucial role in reducing progression of brain ailments such as Alzheimer’s, Parkinson’s, and Huntington’s diseases.
Naringin can be administered in the form of Capsule, Food, Liquid, and Pill. Notably, no exact dosage of Naringin has been confirmed; therefore, the typical dosage of Naringin extracts ranges from 400mg-1250mg per day. Often, Naringin is supplemented with grapefruit juice and grapefruits to get a standardized dosage.
Naringin Side Effects
Naringin extract is considered safe and contains no severe side effects; however, some mild side-effects such as mild stomach upset and diarrhea may occur.
Naringin extracts in grapefruits causes a general interaction with other drugs; it interacts with calcium channel blockers, cholesterol-lowering drugs, estrogen, sedatives, and medications for high blood pressure. The effects of Naringin in Grapefruit supplements is cumulative, thus consuming it with other medications would lead to increased drug interactions as one continues to take the medication, which may result in more adverse effects. Patients and pregnant mothers are recommended to seek advice and consultation from a fully qualified healthcare professional before using any of these products. Children under the age of 18 should not consume Naringin products.
- Journal of Nutrition: The hypoglycemic effects of hesperidin and naringin are partly mediated by hepatic glucose-regulating enzymes in C57BL/KsJ-db/db mice.
- Epilepsy Behavior: Naringin ameliorates pentylenetetrazol-induced seizures and associated oxidative stress, inflammation, and cognitive impairment in rats: possible mechanisms of neuroprotection.
- Neurochemistry International: Neuroprotective effect of naringin, a dietary flavonoid against 3-nitropropionic acid-induced neuronal apoptosis.
- Pharmacology Biochemistry and Behavior: Naringin ameliorates memory deficits in experimental paradigm of Alzheimer's disease by attenuating mitochondrial dysfunction.
- Anticancer Research: Naringin inhibits tumor growth and reduces interleukin-6 and tumor necrosis factor α levels in rats with Walker 256 carcinosarcoma.
- Journal in Agriculture and Food Chemistry: Changes in plasma lipid and antioxidant activity in rats as a result of naringin and red grapefruit supplementation.
- Journal of Applied Toxicology: Combined treatment with naringin and vitamin C ameliorates streptozotocin-induced diabetes in male Wistar rats.
- Phytotherapy Research: Preventive effects of hesperidin, glucosyl hesperidin and naringin on hypertension and cerebral thrombosis in stroke-prone spontaneously hypertensive rats.