A weight loss supplement can include Celastrol as a main ingredient. It should be duly noted, however that this ingredient has a low index in therapeutic rankings, that it would be best to consult a doctor or a physician first to get professional advice before taking Celastrol for its benefits.
In RA trials, 60 mg/day of T2 (a chloroform-methanol extract of T. wilfordii ) for 12 weeks has been evaluated, as well as ethanol/ethyl alcohol root extract 180 to 360 mg/day. Few long-term studies have evaluated the use of 1 mg/kg/day of T2 for up to 5 years; however, adequate safety data during the same time period are limited. The effective antifertility dose has been suggested at one-third the recommended dose for treatment of arthritis; however, quality clinical trials are lacking to confirm efficacy and safety.
It should be noted that this plant has a very low therapeutic index (difference between the effective dose and the toxic dose) and that overdosing is both easy to do and critical; supplementation is usually avoided for this reason.