What is Celastrol?
Celastrol is a potent anti-inflammatory that is extracted from the root bark of an ivy-like vine in China. Celastrol was used for years as a natural remedy for inflammatory conditions. Celastrol is a potent anti-inflammatory that is extracted from the root bark of an ivy-like vine in China. Celastrol was used for years as a natural remedy for inflammatory conditions. Several pharmaceutical companies are studying its multiple properties and have found it to be quite intensely immunosuppressive as well as anti-inflammatory. Celastrol inhibits macrophage activation, MHC I and II processing, TNF-alpha, IL1, IL2, and IL6.
- It has the function of analgesia and stability and effect on the central nervous system of choline;
- It has the function of promoting skin metabolism and has a good effect for skin ulcers and other skin diseases;
- With the function of clearing away heat and detoxifying, clearing damp, subsidence of swellingand diuretic;
- With the function of antibacterial and dissolving stones;
- It has the function of strengthen blood vessels and promoting blood circulation.
How Celastrol works:
Celastrol has the abilities to inhibit proliferation, induce apoptosis and suppress invasion and metastasis of tumor cells. Structure and activity analysis based on celastrol semi-synthetic derivatives revealed that the quinone methide moiety is required for its antitumor activity. The heat shock protein HSP90 chaperone machinery and NF-κB signaling are two principal pathways targeted by celastrol. The optimization of solubility and identification of tumor specific targets is required for further developing celastrol and its derivatives as clinically useful anticancer agents.
In RA trials, 60 mg/day of T2 (a chloroform-methanol extract of Tripterygium wilfordii) for 12 weeks has been evaluated, as well as ethanol/ethyl alcohol root extract 180 to 360 mg/day. Several long-term studies have evaluated the use of 1 mg/kg/day of T2 for up to 5 years; however, adequate safety dataduring the same time period are limited.
Clinically important adverse events have been reported in clinical trials. GI upset, male and female infertility, and immune suppression are common side effects of thunder god vine.
Where to buy Celastrol:
If you want to buy capsule products, please select the Amazon. If you want to buy extract powder, please choose us. More detailed information about the high-quality suppliers, please click here: www.best-dietary-supplements.com