Thunder God Vine's side effects are documented in cases where it was used to treat various ailments. Depending on the overall dosage, Celastrol can have a potentially negative and severe complications. The skinned root and leaves have to be prepared properly, or else it will be highly poisonous.In the preceding studies and researches shown above, adverse gastrointestinal side effects such as nausea, indigestion and diarrhea was present and experienced by many test subjects. There were also cases of upper respiratory tract infections. It may also possibly cause non-direct and lasting side effects such as migraines, menstrual changes, skin rashes and hair loss. Celastrol can also be dormant and lay in wait until a longer period has passed, then have a long-term side effect suddenly come up. Women who have participated and those who have habitually taken the herb in a span of 5 years and longer have been examined and shown to have decreased bone strength with lack of bone mineral deposits. High dosages of Celastrol is not recommended as it can severely weaken a person's autoimmune system. People with HIV/AIDS should stay away from consuming this supplement. It may also adversely affect male fertility by changing sperm count and potency.