As an antioxidant, silymarin scavenges for free radicals that can damage cells exposed to toxins. Silymarin has been said to be at least ten times more potent in antioxidant activity than vitamin E. It increases glutathione in the liver by more than 35% in healthy subjects and by more than 50% in rats. Glutathione is responsible for detoxifying a wide range of hormones, drugs, and chemicals. High levels of glutathione in the liver increases its capacity for detoxification.Silymarin also increases the level of the important antioxidant enzyme superoxide dismutase in cell cultures. It stimulates protein synthesis in the liver, which results in an increase in the production of new liver cells to replace the damaged ones. Silymarin inhibits the synthesis of leukotrienes (mediators of inflammation, which can result in psoriasis, among other things).