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What is Apigenin

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A Potent & Powerful Bioflavonoid Compound That Can Fight Cancers

Apigenin happens to be a Bioflavonoid, a flavone compound, which is contained in a wide range of herbs and plants. Most apigenin is extracted from the Asteraceae or the Matricaria recutita L. flowering plants, after being isolated from them. Other sources of apigenin include basil, beer, chamomile tea, flax, grapefruits, licorice, onions, red wine, and many others. Consuming apigenin at higher doses is known to reduce anxiety, while it may also act as a sedative at even higher doses. It has also become known for being an extremely anti-cancer compound that can beneficially protect against a wide range of cancers, but these are not the only benefits of this compound.

Apigenin Benefits

While no effects are observed at normal dosages, it has been noted that apigenin tends to act as a benzodiazepine ligand, which results in anxiolytic effects, as seen in studies like “Apigenin, a component of Matricaria recutita flowers.” Apparently, this is what enables apigenin to act as a muscle relaxant and/or sedative. Studies like “Quercetin, kaempferol and biapigenin” also show that apigenin can protect the neurological system from excitotoxicity and prevent calcium from building up in the neural mitochondria, specifically in the form of Biapigenin. 

Studies like “Suppression of inducible cyclooxygenase” reveal that apigenin utilizes lipopolysacchraide influence in order to suppress the induction of COX2 and NO-synthase enzymes in macrophages. It has been seen in studies like “Effects of apigenin on steroidogenesis” that apigenin modifies the thromboxane A2 (TBXA2) receptor and the activity of aromatase in such a manner that it results in an increase in testosterone activity, even when low concentrations of apigenin are consumed.

In vivo studies like “Selective growth-inhibitory, cell-cycle deregulatory” also conclude that apigenin is among those Bioflavonoid compounds, which happen to be highly sensitive to promote the selective death of cancer cells. Other studies like “Effects of dietary flavonoids” also indicate that apigenin inhibits the cancer cell cycle, increases the efficacy of the hepatic detoxification enzyme, lowers oxidative stress, and produces anti-inflammatory effects to some extent.

According to several animal-based studies, such as “Genotoxicities of nitropyrenes,” apigenin apparently also beneficially responds to exogenous bacteria and toxins by exerting anti-mutagenic properties. Another study, “Inhibitory effect of apigenin,” also suggests that apigenin even inhibits ornithine decarboxylase, which is an enzyme that encourages certain tumors to grow.

Apigenin Dosage

For those who want to take apigenin for general health and well-being, it should be enough to consume the fruits and vegetables that contain this Bioflavonoid compound. To benefit from its anxiolytic effects, the study “Apigenin, a component of Matricaria recutita flowers” suggests that doses between the range of 3 mg and 10 mg per kg bodyweight should prove to be effective. Moreover, reductions in anxiety and/or sedation can be induced if the dosage is raised between the range of 30 mg and 100 mg per kg bodyweight. Currently, the proper oral dosage for apigenin to result in an increase in testosterone activity remains uncertain.

Apigenin Side Effects

No studies have reported any apparent toxicity when apigenin has bee given in doses via food intake. No other side effects have been observed, although minor local irritation might be experienced, which will go away without requiring any additional medical intervention or treatment. 

Warnings

In vivo studies like “Apigenin: a promising molecule” also confirm that adverse metabolic reactions are very unlikely to occur when apigenin is taken as a part of a normal diet. In fact, studies like these assure that apigenin can prove to be quite beneficial in fighting most types of cancers, without any serious side effects.

References:

  1. Planta Med: Apigenin, a component of Matricaria recutita flowers, is a central benzodiazepine receptors-ligand with anxiolytic effects. 
  2. Neurotox Res: Quercetin, kaempferol and biapigenin from Hypericum perforatum are neuroprotective against excitotoxic insults. 
  3. Carcinogenesis: Suppression of inducible cyclooxygenase and inducible nitric oxide synthase by apigenin and related flavonoids in mouse macrophages. 
  4. J Nutr Biochem: Effects of apigenin on steroidogenesis and steroidogenic acute regulatory gene expression in mouse Leydig cells. 
  5. Biochem Biophys Res Commun: Selective growth-inhibitory, cell-cycle deregulatory and apoptotic response of apigenin in normal versus human prostate carcinoma cells. 
  6. Biochem Pharmacol: Effects of dietary flavonoids on major signal transduction pathways in human epithelial cells. 
  7. Mutat Res: Genotoxicities of nitropyrenes and their modulation by apigenin, tannic acid, ellagic acid and indole-3-carbinol in the Salmonella and CHO systems. 
  8. Cancer Res: Inhibitory effect of apigenin, a plant flavonoid, on epidermal ornithine decarboxylase and skin tumor promotion in mice. 
  9. Pharm Res: Apigenin: a promising molecule for cancer prevention. 

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